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Medicine recalls and shortages › Drug Safety Update › 12 Mar 2025
Drug Safety Update

Prolonged

Published on 12 Mar 2025 · source: MHRA — Medicines and Healthcare products Regulatory Agency
The indication for the treatment of post-operative pain has been removed from the licences of all prolonged release opioids due to the increased risk of persistent post-operative opioid use (PPOU) and…
Drug Safety Update on GOV.UK ↗ All events: Prolonged

What this means

Drug Safety Update is the MHRA bulletin for healthcare professionals: new safety information, restrictions of use and recommendations for monitoring.

Summary

The indication for the treatment of post-operative pain has been removed from the licences of all prolonged release opioids due to the increased risk of persistent post-operative opioid use (PPOU) and opioid-induced ventilatory impairment (OIVI).

Tracked from information published by the MHRA and the NHSBSA. This information is for guidance only and does not replace advice from your doctor or pharmacist.