Improving Information Supplied with Gabapentinoids (Pregabalin/Gabapentin), Benzodiazepines and Z
Published on 8 Jan 2026 · source: MHRA — Medicines and Healthcare products Regulatory Agency
Drug Safety Update on GOV.UK ↗ All events: Improving Information Supplied with Gabapentinoids (Pregabalin/Gabapentin), Benzodiazepines and Z
What this means
Drug Safety Update is the MHRA bulletin for healthcare professionals: new safety information, restrictions of use and recommendations for monitoring.
Summary
The MHRA has reviewed the warnings regarding addiction, dependence, withdrawal, and tolerance for gabapentin, pregabalin, benzodiazepines, and z-drugs. The findings (detailed in the Public Assessment Report) were that it was necessary to strengthen these warnings in the product information and on packaging to better inform healthcare professionals and patients of these known risks.